I suspect that will depend on what you will accept as evidence. Some possible avenues of exploration:
1. Quantum physics.
2. Unio mystica or “nondual” peak experience.
3. Sartre’s existential nausea.
4. Perceptions evoked by psilocybin.
On the other hand, we also have what can be considered “supportive” evidence for substance dualism, such as:
1. Experiencing astral projection.
2. Ian Stevenson’s research on reincarnation.
3. The reports of various religious adherents regarding visiting other realms of existence.
4. Encountering a ghost or spiritual entity.
Then again, having researched and/or personally experienced all of these myself, I’d have to say that dualism (of any sort) is an operational state that pulls at our consciousness like gravity, while nonduality is an enveloping and interpenetrating foundational substrate that - in a cyclical and iterative dialectic of creation and destruction - both generates and dissipates that duality. I suspect that the relationship between the two even hints at the origins of consciousness itself…like the impact of tidal zones on evolution. They are not, therefore, mutually exclusive, but synergistically linked.
My 2 cents.
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